Post-exercise ketosis
Simply restricting carbohydrates will establish ketonuria (presence of ketones in the urine) given enough time (typically 3-4 days). The requirements for the establishment of ketosis are discussed in detail in chapter 4 but are briefly reviewed here. Additionally, exercise interacts with carbohydrate restriction and affects ketosis. This chapter discusses the role of exercise, both in helping to establish ketosis, as well as its impact on ketosis once established.
A recap of ketogenesis
Ketosis
requires a shift in the liver away from triglyceride synthesis and towards free
fatty acid (FFA)
oxidation and ketone body formation. Blood glucose must also drop, lowering
insulin and increasing glucagon and decreasing the I/G ratio. Along with this
hormonal shift, there must be adequate FFA present for the liver to produce
ketones.
Exercise
is inherently ketogenic and all forms of exercise will increase the rate at
which the liver
releases its glycogen, helping to establish ketosis. As the rapid establishment
of ketosis is important for individuals using the CKD approach (who only have
5-6 days to maximize their time in ketosis), strategies for entering ketosis
are discussed. The overall effects of exercise on ketone concentrations is also discussed.
Section 1: Aerobic exercise
It has
been known for almost a century that ketones appear in higher concentrations in the blood
following aerobic exercise (1). During aerobic exercise, liver glycogen
decreases, insulin decreases,
glucagon increases and there is an increase in FFA levels in the bloodstream.
During aerobic
exercise, there is a slight increase in blood glucose uptake which peaks around
ten minutes.
To maintain blood glucose, the liver will increase liver glycogen breakdown,
keeping blood
glucose stable for several hours. Thus, the
overall effect of aerobic exercise is to increase the production of ketone
bodies .The
increase in ketone bodies during exercise is smaller in trained versus
untrained individuals,
due to decreased FFA mobilization during exercise .
Aerobic
exercise can quickly induce ketosis following an overnight fast. One hour at 65% of maximum
heart rate causes a large increase in ketone body levels. However, ketones do not contribute
to energy production to any significant degree . Two hours of exercise at
65% of maximum
heart rate will raise ketone levels to 3mM after three hours. High levels of
ketonemia (similar
to those seen in prolonged fasting) can be achieved five hours post-exercise .
This increase in ketone bodies post exercise allows for glycogen replenishment in the muscle. Since the brain will not be using glucose for energy, any incoming carbohydrates can be diverted to the muscles . Obviously, if no dietary carbohydrates are consumed following training, ketosis should be maintained.
This increase in ketone bodies post exercise allows for glycogen replenishment in the muscle. Since the brain will not be using glucose for energy, any incoming carbohydrates can be diverted to the muscles . Obviously, if no dietary carbohydrates are consumed following training, ketosis should be maintained.
Aerobic
exercise decreases blood flow to the liver which should decrease the
availability of FFA for
ketogenesis . However, this is offset by an increase in FFA availability and,extraction
by the liver .
If ketone
body levels are low at the onset of exercise, there is an increase in ketone concentrations
during exercise. If ketone body levels are high during exercise (above 2-3
mmol), exercise
has little effect on overall ketone body levels simply because they are already
high (i.e. levels of
ketosis will not deepen). This reflects one of the many feedback loops to
prevent ketoacidosis
during exercise and afterwards . High levels of ketones inhibit further fat breakdown
during exercise although insulin levels still decrease. The primary fuel for
exercise is FFA and
the body will simply use the FFA already present in the blood for fuel.
Section 2: High-intensity exercise
Very
little research has looked at the effects of high-intensity exercise on
establishing ketosis or post-exercise ketosis. However, we can make some
educated guesses based on what is known to occur during high-intensity
exercise.
During
high-intensity exercise, the same overall hormonal picture described above
occurs, just to a
greater degree. Adrenaline and noradrenaline increase during high-intensity
activities (both
interval and weight training). The large increase in adrenaline causes the
liver to release liver
glycogen faster than it is being used, raising blood glucose . While this
may impair ketogenesis
in the short term, it is ultimately helpful in establishing ketosis. Insulin
goes down during
exercise but may increase after training due to increases in blood glucose.
Glucagon goes up also helping to establish ketosis. Probably the biggest
difference between high and lowintensity exercise is that FFA release is
inhibited during high-intensity activity, due to increases in lactic acid .
Many
individuals report finding a decrease in urinary ketones (or a complete
absence) Following
the performance of high-intensity exercise. Most likely, this reflects a
temporary decrease in blood FFA concentrations and increase in blood glucose and insulin.
Additionally, the large increase in adrenaline and noradrenaline decreases
blood flow to the liver further decreasing FFA availability for ketone
production.
So while
high-intensity exercise is arguably the quickest way to establish ketosis (due
to its
effects on liver glycogen breakdown), the overall effect of this type of
exercise could be described as temporarily anti-ketogenic. The solution
to this dilemma is simple: follow highintensity activity (to empty liver
glycogen) with low-intensity activity (to provide FFA for ketone formation).
Ten to fifteen minutes of low-intensity aerobics (below lactate threshold)
following intervals or a weight workout should help to reestablish ketosis by
lowering blood glucose and providing FFA for the liver.The impact of different
forms of exercise on ketosis appears in table 1 :
Summary
Low-intensity
aerobic exercise, below the lactate threshold, is useful for both establishing ketosis
following an overnight fast as well as deepening ketosis. High-intensity
exercise will more quickly establish ketosis by forcing the liver to release
glycogen into the bloodstream. However it can decrease the depth of ketosis by
decreasing the availability of FFA. Performing ten minutes or more of
low-intensity aerobics following high-intensity activity will help reestablish
ketosis after high-intensity activity.
Guidelines for Establishing and
Maintaining Ketosis
1. After a
carb-up, if not weight training the following day, perform 45’+ of
low-intensity aerobic exercise (~65% of maximum heart rate) to deplete liver
glycogen and establish ketosis without depleting muscle glycogen. Interval
training will establish ketosis more quickly by depleting liver glycogen but
will negatively affect your leg workout.
OR
2. Perform
a high-intensity workout (weight training or intervals) followed by 10-20’ of
lowintensity aerobics to provide adequate FFA for the liver to produce ketones.